ISBN 9783843929004

978-3-8439-2900-4, Reihe Medizinische Chemie

Rajathees Rajaratnam
Design and Synthesis of Enantiopure Organometallic Kinase Inhibitors as Potential Chemotherapeutics

255 Seiten, Dissertation Philipps-Universität Marburg (2016), Hardcover, B5

Zusammenfassung / Abstract

Main interest of the Meggers group is to explore the structural aspects of octahedral transition metal complexes, often in combination with other features, for applications in organic synthesis and life sciences. A variety of different transition metals have been applied successfully as structural templates to access highly potent and selective kinase inhibitors. During this effort, the effectiveness of metal complexes as kinase inhibitors with potential anticancer properties has repeatedly been proven. These ambitions led from initial half sandwich complexes to highly sophisticated octahedral complexes. In the current thesis, the challenge to selectively synthesise a desired enantiomer is presented highlighting the application of symmetric polydentate ligands and chiral polydentate ligands.