ISBN 9783843948395

978-3-8439-4839-5, Reihe Biochemie

Jannis Lawatscheck
Mechanistic and Conformational Studies on the Glucocorticoid Receptor and the Molecular Chaperone Hsp90

212 Seiten, Dissertation Technische Universität München (2021), Softcover, A5

Zusammenfassung / Abstract

Together with the Hsp70 system, in a regulated, concerted manner, the Hsp90 machinery processes a variety of different client proteins in a plethora of pathways, herein ensuring proteostasis. In this work, using different biophysical and biochemical assays, the interaction of the full-length glucocorticoid receptor with the chaperone systems via distinct conformational rearrangements was investigated. Moreover, the conformational dynamics of the Hsp90 chaperone regarding its catalytic activity and the methylation of a specific lysine in the C-terminal domain were studied.