ISBN 9783843948661

978-3-8439-4866-1, Reihe Organische Chemie

Maximilian Räuchle
Kopplung von Peptiden an Oligoribonukleotide ohne Schutzgruppen

182 Seiten, Dissertation Universität Stuttgart (2021), Softcover, A5

Zusammenfassung / Abstract

Peptido RNAs are 5'-phosphorylated oligoribonucleotides connected to the a-amino group of a peptide via a phosphoramidate linkage. Previously, peptido RNAs with statistical chain length distributions could be detected as products of spontaneous reactions between amino acids and ribonucleotides in an aqueous condensation buffer. Although occupying a niche role in today’s biochemistry, the formation of peptido RNAs as possible intermediate evolutionary species may be important in relation to the molecular origin of life. To enable in- depth biophysical studies of these modified RNAs, synthetic protocols for obtaining monodisperse, pure compounds are described in this dissertation.