ISBN 978-3-8439-5182-1

978-3-8439-5182-1, Reihe Organische Chemie

Bernhard Markus Krause
New enzyme-triggered CO-releasing molecules as potential biologically active agents

541 Seiten, Dissertation Universität Köln (2022), Hardcover, A5

Zusammenfassung / Abstract

In this dissertation, the concept of enzyme-triggered CO-releasing molecules (ET-CORMs) was exploited and extended by developing potential antibiotic agents to overcome antibacterial resistance. A reliable and efficient 7-step stereoselective synthesis was developed to ensure access to penicillin-conjugated ET-CORM (PenET-CORM) prodrugs. Additionally, penicillin-conjugates with fluorescent probes were prepared.

Furthermore, ET-CORM conjugates with the ketoacid phenylpyruvate and the immunometabolite itaconate were successfully synthesised and characterised with regard to their CO release kinetics.